“伦敦病人”现身:全球艾滋病治愈第二人

2021年1月15日
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全球有数千万艾滋病病毒携带者,他们靠服药维持正常生活,但完全治愈恢复的迄今只有两例。最近第二例治愈者公开了自己的身份,他和此前的“柏林病人”都是通过骨髓移植彻底治愈了艾滋病。治愈的背后还有哪些故事?两例治愈者的出现,是否意味着这一疗法可以推广?

“伦敦病人”现身:全球艾滋病治愈第二人

The “London Patient,” Cured of H.I.V., Reveals His Identity

艾滋病治愈者“伦敦病人”身份公布

A year after the “London Patient” was introduced to the world as only the second person to be cured of H.I.V., he is stepping out of the shadows to reveal his identity: He is Adam Castillejo.

去年,“伦敦病人”的案例被公诸于世,他或将成为史上第二例被治愈的艾滋病患者。一年过后,这位病人终于现身并公布了自己的身份:他叫亚当·卡斯蒂列霍。

Last March, scientists announced that Mr. Castillejo, then identified only as the “London Patient,” had been cured of H.I.V. after receiving a bone-marrow transplant for his lymphoma. The donor carried a mutation that impeded the ability of H.I.V. to enter cells, so the transplant essentially replaced Mr. Castillejo’s immune system with one resistant to the virus. The approach, though effective in his case, was intended to cure his cancer and is not a practical option for the widespread curing of H.I.V. because of the risks involved.

去年3月,科学家宣布,彼时仅被称呼为“伦敦病人”的卡斯蒂列霍在接受了治疗淋巴瘤的骨髓移植手术后,治愈了艾滋病。骨髓捐赠者携带的基因突变可以阻断HIV病毒进入细胞,因此移植手术其实是给卡斯蒂列霍换上了一套可以抵抗HIV病毒的免疫系统。这一方法原本旨在治疗他的癌症,虽然对其艾滋病奏效,但考虑到所涉及的风险,对于艾滋病的广泛治疗来说并不是一个切实可行的选择。

Only one other individual with H.I.V. — Timothy Ray Brown, the so-called Berlin Patient, in 2008 — has been successfully cured, and there have been many failed attempts. In fact, Mr. Castillejo’s doctors could not be sure last spring that he was truly rid of H.I.V., and they tiptoed around the word “cure,” instead referring to it as a “remission.”

除了卡斯蒂列霍,另外只有一名艾滋病患者在2008年被成功治愈,那就是人称“柏林病人”的蒂莫西·雷·布朗,而失败的案例却数不胜数。实际上,在去年春天,卡斯蒂列霍的医生还不敢确定他是否真正摆脱了艾滋病,他们小心翼翼地回避着“治愈”这个词,将其称作“缓解”。

It’s really important that it wasn’t a one-off, it wasn’t a fluke. It can be very important for people to have these kinds of beacons of hope.

艾滋病的成功治愈不是出于侥幸的昙花一现,这对于我们来说很重要,我们需要守住这样希望的灯塔。

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